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09-Jan-2020 04:27

Patients with active RAS have an increased proportion of gamma-delta T cells compared with control subjects and patients with inactive RAS.

Gamma-delta T cells may be involved in antibody-dependent cell mediated cytotoxicity (ADCC).

Recurrent aphthous stomatitis (RAS) is a common ulcerative inflammatory condition of the oral cavity; it typically starts in childhood or adolescence as small recurrent, painful, round or ovoid ulcers with well-defined erythematous margins, like a halo, and a central yellow or gray floor. A positive family history of RAS is common, and the natural history typically involves resolution in the third decade of life.

Not all recurring ulcers represent RAS, however, so the clinician must distinguish localized RAS from lesions arising from an underlying systemic disorder.

Proposed causative factors for RAS include nutritional deficiency, immunologic factors, psychological stress, and dietary allergies, as well as trauma in patients with genetic susceptibility to RAS.

Children with extensive ulcers should receive proper diet and hydration, as they may avoid food intake as well as hydration.The chance of children with RAS-positive parents presenting with RAS is high, up to 90%, while the chance of presentation in children with RAS-negative parents is just 20%.It is interesting to note that the prevalence of presentation has been found to be five times greater in children with high socioeconomic status.Diagnosis of RAS is based on history and clinical features.Topical corticosteroids (TCs) remain the mainstays of treatment.

Children with extensive ulcers should receive proper diet and hydration, as they may avoid food intake as well as hydration.

The chance of children with RAS-positive parents presenting with RAS is high, up to 90%, while the chance of presentation in children with RAS-negative parents is just 20%.

It is interesting to note that the prevalence of presentation has been found to be five times greater in children with high socioeconomic status.

Diagnosis of RAS is based on history and clinical features.

Topical corticosteroids (TCs) remain the mainstays of treatment.

The investigators found significantly lower serum levels of superoxide dismutase, catalase, and glutathione peroxidase in active lesion RAS patients than in patients in the remission stage of RAS or in healthy controls.